Sunday, February 1, 2015

In pursuit of next-generation Ebola stockpile vaccines

Research assistant Georgina Bowyer works on a vaccine for Ebola at The Jenner Institute in Oxford By Kate Kelland and Ben Hirschler LONDON (Reuters) - As West Africa's devastating Ebola outbreak begins to dwindle, scientists are looking beyond the endgame at the kind of next-generation vaccines needed for a vital stockpile to hit another epidemic hard and fast. "We need a stockpile because there will be other outbreaks," said Seth Berkley, chief executive of the GAVI global immunization alliance, which helps bulk-buy vaccines for poor countries. The experimental vaccines now moving into large clinical trials in West Africa target the current Ebola Zaire virus strain, but the next outbreak may be different. "We need to work with the pharmaceutical industry to create second-generation vaccines that would cover not just Ebola Zaire but also Ebola Sudan and perhaps Marburg, perhaps Lassa.








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